Genetic Polymorphism of Cytochrome P450 2C9 (CYP2C9) in Two Ethnic Groups in Iran

Genetic Polymorphism of Cytochrome P450 2C9 (CYP2C9) in Two Ethnic Groups in Iran

Cytochrome P450 2C9 is considered as a vital enzyme for drugs and toxic detoxification in human body. The present study was carried out to assess the distribution of CYP2C9 allele and genotypic variants in two ethnic groups (Fars and Turkman) in the North East of Iran. The present study contained 110 unrelated healthy Turkman origin and 110 unrelated healthy Fars origin people who were referred...

Frequency of Cytochrome P450 2C9 (CYP2C9) Alleles in Three Ethnic Groups in Malaysia

Cytochrome P450 2C9 (CYP2C9) is the major enzyme involved in the metabolism of S-warfarin, an oral anticoagulant drug. Genetic polymorphisms of CYP2C9 gene have been reported and may play significant roles in pharmacogenomics. To date, over 5 CYP2C9 allelic variants have been reported. The most common allelic variants identified include CYP2C9*2 and CYP2C9*3. We conducted an investigation to de...

Genetic Polymorphism of Cytochrome p450 (2C9) Enzyme in Iranian Baluch Ethnic Group

The aim of the present study is to assess and compare the frequencies of the cytochrome P450 CYP2C9 variations in the Baluch ethnic group (n=110) with other ethnic groups. The allele frequencies of CYP2C9*1, CYP2C9*2 and CYP2C9*3 were 80.90%, 11.82% and 7.27%, respectively. 70.90%, 11.82%, 8.18%, 4.55%, 2.73% and 1.82% of subjects were with CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CY...

Effects of cytochrome P450 2C9 polymorphism on bosentan metabolism.

Cytochrome P450 (P450) 2C9 is an important member of the P450 enzyme superfamily, with 58 CYP2C9 allelic variants previously reported. Genetic polymorphisms of CYP2C9 significantly influence the efficacy and safety of some drugs, which might cause adverse effects and therapeutic failure. The aim of this study was to assess the catalytic activities of 38 human CYP2C9 alleles, including 24 novel ...

Effects of pomegranate juice on human cytochrome P450 2C9 (CYP2C9) and tolbutamide pharmacokinetics in rats